This is how the neuroleptic Melperon works


Melperone is a so-called neuroleptic, a drug that acts on the central nervous system and can be used in various mental and neurological disorders. It belongs to a whole group of drugs with the same mechanism of action, but each one has a specific action profile.

Special action profile

Neuroleptics are strong, medium and low-potency drugs. Melperon belongs to the middle group. Its effect is therefore only moderately pronounced, but the side effects are therefore also moderate. Its use is due to the relatively low side effects especially in geriatrics, so in the treatment of the elderly.

Effect of melperone

Melperone is a medicine that works in the brain. It occupies docking sites (receptors) for certain messenger substances (hormones) in the body and in the central nervous system. This will downregulate the effect of these messengers. Its main effect is exhibited by the occupancy of serotonin and dopamine receptors, which are located in certain parts of the brain.

Serotonin works everywhere in the body and fulfills various tasks. Among other things, it controls emotions. If too much serotonin is present in the brain, it can lead to an anxiety disorder, which is why a blockade of the serotonin receptors by melperone has an anxiolytic effect.

Dopamine also has many different functions. Too high a level of dopamine in the brain is associated with psychotic symptoms, such as delusions and hallucinations. By blocking dopamine receptors, melperone can alleviate the symptoms. In addition, melperone has a sleep-inducing and calming effect (sedation).

With these complaints Melperon helps

Because of its properties, melperone helps with sleep disorders, restlessness and anxiety. Illnesses that often cause these symptoms include:

  • depression
  • schizophrenia
  • certain personality disorders
  • dementia

Also in the so-called alcohol elixir, in which, in addition to the above-mentioned complaints, states of confusion also occur, melperone is used.

Melperon is mainly used in geriatrics because, unlike other sedating psychotropic drugs, it has no muscle relaxant effect and thus does not increase the risk of falling for older people.

Dosage of melperone

The dosage of melperone must be determined individually by the attending physician. How many tablets the doctor prescribes depends on the severity of the symptoms and what effect the medication should achieve.

In addition, the age, side-diseases and the weight of the person involved play a role. It can take a few weeks to get the full effect.

Side effects of Melperon

In addition to nausea and vomiting and occasionally allergies, it can lead to low blood pressure (hypotension) and arrhythmia. A side effect typical of the group of neuroleptics is the extrapyramidal motor syndrome. This causes muscle twitching, cramping and movement disorders. If these symptoms occur, Melperon must be discontinued immediately, because later in the extrapyramidal motor syndrome is no longer curable.

It is not possible to drive in the first few days after taking melperone, which is why you should consult your doctor.

Interactions of the drug

Melperon can not be combined with any other drug. Which other drugs can cause dangerous interactions, is in the leaflet. Under no circumstances should Melperon be taken with alcohol or other neuroleptics.

Even medications that also act in the brain, such as some sleep, sedative or analgesics, should be used restrained. Otherwise, the effect of melperone may be increased, leading to increased drowsiness, drowsiness and even respiratory problems.

Contraindications to the drug

The contraindications for Melperon are varied, which is why you can take the drug only after consultation with the attending physician. Known contraindications are an allergy to butyrophenone, liver dysfunction and a so-called malignant neuroleptic syndrome in the past.

For children under 12 years Melperon is in principle not suitable. Particular caution should be exercised during pregnancy and breast-feeding as there are no studies on the use of the drug in this regard.

Instructions for taking Melperon

Melperone tablets often contain the salty form of the active ingredient, melperone hydrochloride. He belongs to the group of butyrophenones, which are derived from the opioid pethidine, a strong analgesic.

It is important to note that you should not take melperone with milk, coffee or tea together, otherwise it may form poorly soluble compounds in the digestive tract.




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