Novaminsulfone (Novalgin®) - controversial analgesic

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  • Novaminsulfone - controversial painkiller
  • Novminsulfone - dangerous side effects

Novaminsulfone is a non-opioid analgesic, also known as metamizole or under the trade name Novalgin® is known. Novaminsulfone has both an analgesic and a fever-lowering and slightly anti-inflammatory effect. The analgesic is usually used as a so-called reserve agent - it is administered when other medications fail to work. When taking the partially serious side effects of Novaminsulfon, the frequency of occurrence, however, is controversial to note.

This is how Novaminsulfone works

Non-opioid analgesics, such as novamine sulfone, unlike the opioid analgesics, do not exert their effect on the opioid receptors. Instead, their effect comes about through the suppression of pain-inducing biochemical processes.

Within non-opioid analgesics, Novalminsulfone belongs to the group of non-acidic painkillers. How exactly the active substances of this group, including Novalminsulfon, act, could not yet be clarified conclusively. However, it is believed that novamine sulfone inhibits the formation of prostaglandins, a group of tissue hormones. They are essential as messengers involved in the process of pain mediation.

When is Novaminsulfone used?

The active ingredient Novaminsulfon is due to its analgesic and antipyretic effect used to treat the following complaints:

  • moderate and severe pain
  • acute as well as chronic pain, such as tumor pain
  • high fever (only on the condition that other drugs do not work)

Unlike most other non-opioid analgesics, Novaminsulfone also has one anticonvulsant effect. Therefore, it may be used for pain relief in colic bile ducts or urinary tract.

5 facts about Novaminsulfone - © rawpixel

Dosage of Novaminsulfone

Novaminsulfone or Novalgin® is available in the form of drops, tablets and suppositories as well as a solution for injection. The dosage of Novaminsulfon depends on the existing symptoms and should always be clarified with the attending physician. In high fever or chronic pain, single doses of 500 milligrams or 1000 milligrams are recommended.

Depending on the nature of the application, the effect of novaminsulfone starts about 30 to 60 minutes after administration. If Novaminsulfon taken orally and at the same time with food, this may have a delayed onset of action.

Novaminsulfone: Contraindicators

Novaminsulfone, for example in the form of Novalgin®, should not be taken if there is an intolerance to the active substance. Novaminsulfon should not be used even if the production of the red blood pigment is disrupted.

Likewise, during the pregnancy and the lactation and in infants under three months to refrain from the use of Novaminsulfon.

children Under ten years, Novaminsulfon should be given only in consultation with a doctor and in the form of suppositories, but not in the form of tablets. Suppositories of 300 milligrams should first be administered to children from the age of four, suppositories of 1000 milligrams first to adolescents from the age of 15 years.

Likewise, should certain diseases be dispensed with Novaminsulfon. These include acute hepatic porphyria (liver dysfunction) as well as a deficiency in the enzyme glucose-6-phosphate dehydrogenase. People who have low blood pressure should not receive Novaminsulfone intravenously as this may cause a sharp drop in blood pressure.

Interactions with Novaminsulfone

Interactions mainly occur with drugs that contain the active ingredient ciclosporin, since Novaminsulfon lowers the cyclosporin level. In addition, the effectiveness of diuretics can be mitigated by Novaminsulfon.

Likewise, concurrent use of novamine sulfone and the active ingredient chlorpromazine, which is used to treat psychotic disorders, may result in a significant decrease in body temperature.

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